As the nation grapples with the strictures of Prohibition, Rosa Barclay lives on a Southern California rye farm with her volatile husband, John, who has lately found another source of income far outside the federal purview. Mother to eight children, Rosa mourns the loss of four who succumbed to the mysterious wasting disease that is now afflicting young Ana and Miguel. Two daughters born of another father are in perfect health. When an act of violence shatters Rosa's resolve to maintain her increasingly dangerous existence, she flees with the children and her precious heirloom quilts to the mesa where she last saw her beloved mother alive.